Alert Cerebral Folate Deficiency

Folinic Acid Supplements & Spinal Taps

If you have any questions, please contact our office for further details.

Cerebral Folate deficiency is well known within our field. It is a reported finding in some cases of mitochondrial disease as documented by a very low spinal fluid of a chemical known as 5-MTHF. On the scale that is commonly used, reported levels that typically require intervention are 10-25 with normal being 40-150. SOME patients in that low range of 10-25 do respond to doses of folinic acid, showing some improvement or stabilization of their clinical symptoms. In Dr Kendall's personal experience, however, as well as that of some of her trusted colleagues in the field, most patients do not respond to this therapy. For that reason, Dr Kendall is very skeptical of retapping patients who have previously tested in the normal range. She does not believe this practice meets the current standard of care. 

Dr Kendall feels that there needs to be a very substantial reason to put a child or adult, especially those who may already be in a weakened condition, through the discomfort and possible danger of a spinal tap. She strongly recommends that families seek a second opinion, especially from their treating physician, before they consider taking this step.