There is a dosing debate going on with CoQ10 and Creatine in mitochondrial disorders. Click here to listen Dr Fran Kendall discuss this debate and offer more background on the subject.
CoQ10 is a cofactor in the electron transport chain as well as an antioxidant and has been a cornerstone of supportive mitochondrial disease treatment for many years. Typical dosing of CoQ10 is 5-15mg/kg of body weight, although "high dose" CoQ10 is common for patients with mitochondrial disease, as well as other mitochondrial-related disorders which are a result of secondary mitochondrial dysfunction (such as ALS).
Recent studies examining the effect of high dose (2700 mg/day) CoQ10 in patients with ALS concluded no improvement in patient symptoms with use of the high dose. Additional studies with mitochondrial patients using 500-800 mg/day of the Tischon brand CoQ10 (such as QGel from epic4health.com, a form of CoQ with better absorption and bioavailability) demonstrated mild to moderate improvements in symptoms such as fatigue and low muscle tone.
Dr. Kendall's experience as well as her clinical research suggests several general findings about use of CoQ10 in Mito patients.
As a result, Dr. Kendall suggests that when using CoQ10 to treat mitochondrial disease symptoms, "more is not necessarily better". Patients showed mild-moderate improvements even while on a moderate dose (specifically, 20 mg/kg/day in children, and 1000-2000 mg/day in adults). In addition, increased blood levels of CoQ10 do not necessarily correlate with increased symptom relief.
Side effects of CoQ10 may include:
Use of the supplement Creatine has recently gained more attention - as well as confusion- amongst mitochondrial disease patients, as well as the general population due to use by athletes.
Creatine is converted in the body to phosphocreatine (an anaerobic pre-cursor to ATP). This naturally occurring substance is thought to help generate extra energy when taken as a supplement in people with mitochondrial disorders. However, while creatine has shown positive short-term improvements in patients with Mito and neuromuscular diseases, there are documented side effects with creatine use.
Specifically, side effects of creatine can include:
Dr. Kendall suggests that Mito patients who primarily experience muscle-related symptoms, such as pain and hypotonia, may find creatine to be beneficial. However, Dr. Kendall cautions against using any form other than a medical grade product, such as Neotine, as other products are potentially toxic (dosing is typically 5g/day for children, 10g/day in adults). In addition, the potential for kidney dysfunction should always be discussed with the prescribing physician.
This post is not meant to be a recommendation or a substitute for professional advice and services rendered by qualified doctors, allied medical personnel, and other professional services. The responsibility for any use of this information, or for proper medical treatment, rests with you.